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- Embassy Suites by Hilton Lexington/UK Coldstream
- Fairfield Inn & Suites by Marriott Lexington North
- 21c Museum Hotel Lexington
- Candlewood Suites Lexington Medical District, an IHG Hotel
- The Campbell House Lexington, Curio Collection by Hilton
- Hyatt Place Lexington
- Holiday Inn Lexington - Hamburg, an IHG Hotel
- Days Inn & Suites by Wyndham Lexington
- Home2 Suites by Hilton Lexington University / Medical Center
- Origin Lexington a Wyndham Hotel
- Red Roof Inn Lexington
- Hampton Inn I-75 Lexington/Hamburg Area